The NADPH consumption regulates the NADPH-producing pathways (pentose phosphate cycle and malic enzyme) in rat adipocytes

The changes in the activity of the pentose phosphate cycle and the malic enzyme produced by the activation or inhibition of different NADPH-consuming pathways have been studied. The inhibition of the fatty acid synthesis by kynurenate produced a decrease in the flux through the pentose phosphate cyc...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular biochemistry 1987-03, Vol.74 (1), p.77-81
Main Authors: Fabregat, I, Revilla, E, Machado, A
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Animals
Carmustine - pharmacology
Female
Kinetics
Kynurenic Acid - pharmacology
Malate Dehydrogenase - metabolism
NADP - metabolism
Oxidation-Reduction
Pentose Phosphate Pathway - drug effects
Peroxides - pharmacology
Rats
Rats, Inbred Strains
tert-Butylhydroperoxide
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The changes in the activity of the pentose phosphate cycle and the malic enzyme produced by the activation or inhibition of different NADPH-consuming pathways have been studied. The inhibition of the fatty acid synthesis by kynurenate produced a decrease in the flux through the pentose phosphate cycle and a diminution in the malic enzyme pathway. The incubation of the adipocytes in the presence of ter-butyl-hydroperoxide, a compound which is metabolized via a NADPH-consuming pathway, produced a big increase in the pentose phosphate cycle and the malic enzyme activities. The regulation of these NADPH-producing pathways by the NADPH/NADP ratio is discussed.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00221914