Developmental abnormalities and cortical sulcal enlargement in psychosis

Neurodevelopmental abnormalities and cortical sulcal enlargement both occur in schizophrenia. To test the hypothesis that these abnormalities were related, CT scans from 164 psychotic patients (80 with schizophrenia) were reviewed. Neurodevelopmental abnormalities were observed in 11%. Abnormalities...

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Bibliographic Details
Published in:Schizophrenia research 1995-08, Vol.16 (2), p.121-125
Main Authors: Honer, William G., Squires-Wheeler, Elizabeth, Smith, Geoffrey N., Sharif, Zafar, Chan, Steve, Gewirtz, George
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Bipolar Disorder - diagnostic imaging
Bipolar Disorder - psychology
Brain Damage, Chronic - diagnostic imaging
Brain Damage, Chronic - psychology
Cerebral Cortex - abnormalities
Cerebral Cortex - diagnostic imaging
Cortical atrophy
CT scan
Depressive Disorder - diagnostic imaging
Depressive Disorder - psychology
Female
Humans
Male
Medical sciences
Middle Aged
Neurocognitive Disorders - diagnostic imaging
Neurocognitive Disorders - psychology
Neurodevelopment
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychosis
Psychotic Disorders - diagnostic imaging
Psychotic Disorders - psychology
Risk Factors
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenic Psychology
Tomography, X-Ray Computed
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Summary:Neurodevelopmental abnormalities and cortical sulcal enlargement both occur in schizophrenia. To test the hypothesis that these abnormalities were related, CT scans from 164 psychotic patients (80 with schizophrenia) were reviewed. Neurodevelopmental abnormalities were observed in 11%. Abnormalities were equally prevalent in schizophrenia and other psychotic disorders. Cortical sulcal enlargement was observed in 39% of patients with schizophrenia, and was not associated with developmental abnormalities. Different mechanisms may contribute to distinct structural abnormalities.
ISSN:0920-9964
1573-2509
DOI:10.1016/0920-9964(94)00070-O