HLA Associations With Leukemia

Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymph...

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Bibliographic Details
Published in:Blood 1987-07, Vol.70 (1), p.227-232
Main Authors: Bortin, Mortimer M., D’Amaro, Joseph, Bach, Fritz H., Rimm, Alfred A., van Rood, Jon J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
Europe
Evaluation Studies as Topic
Female
Hematologic and hematopoietic diseases
HLA Antigens - analysis
HLA Antigens - genetics
HLA-A Antigens
HLA-C Antigens
Humans
Infant
Leukemia - epidemiology
Leukemia - genetics
Leukemia - immunology
Leukemia, Lymphoid - genetics
Leukemia, Lymphoid - immunology
Leukemia, Myeloid - genetics
Leukemia, Myeloid - immunology
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
North America
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Summary:Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (relative risk — 2.64, P < 0.0002), acute myelogenous leukemia (relative risk = 1.92, P < 0.0007), and chronic myelogenous leukemia (relative risk =2.07, P < 0.002; P values adjusted for multiple comparisons). The frequency of Cw4 was elevated in patients with acute lymphoblastic leukemia (relative risk = 2.01, P < 0.0003), acute myelogenous leukemia (relative risk =2.06, P < 0.0002), and chronic myelogenous leukemia (relative risk = 2.14, P < 0.0008). The frequency of Aw19 was significantly decreased in patients with acute myelogenous leukemia (relative risk = 0.68, P < 0.01) and chronic myelogenous leukemia (relative risk = 0.59, P < 0.005). None of the other 32 HLA antigens investigated had a statistically significant association with leukemia. The data suggest that Cw3 and Cw4 may be markers for leukemia susceptibility genes, while Aw19 may be a marker for decreased susceptibility to leukemia.© 1987 by Grune & Stratton, Inc. 0006-497l/87/7001-0034$3.00/0
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V70.1.227.227