Cloning and Sequence Analysis of the Mouse Smooth Muscle γ,-Enteric Actin Gene

Actin represents one of the most highly conserved families of proteins in evolution. The work presented here describes the molecular characterization of the mouse smooth muscle (enteric) γ-actin gene (SMGA). It represents the largest isoactin gene characterized to date, measuring aver 23,000 bp from...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1995-07, Vol.28 (2), p.154-162
Main Authors: Szucsik, John C., Lessard, James L.
Format: Article
Language:English
Subjects:
Actins - genetics
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Cloning, Molecular
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Humans
Mice - genetics
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Molecular Weight
Muscle, Smooth - chemistry
Nucleic Acid Conformation
Rats
Regulatory Sequences, Nucleic Acid
Sequence Alignment
Sequence Homology, Nucleic Acid
Species Specificity
Transcription, Genetic
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Description
Summary:Actin represents one of the most highly conserved families of proteins in evolution. The work presented here describes the molecular characterization of the mouse smooth muscle (enteric) γ-actin gene (SMGA). It represents the largest isoactin gene characterized to date, measuring aver 23,000 bp from the transcription start site to the polyadenylation signal. The gene is divided into nine exons and encodes a mature actin protein of 374 amino acids. Putative regulatory elements are noted as well as regions of the gene that have the potential to form non-B DNA conformations that may influence gene expression.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1995.1126