L-Platelet Activating Factor Induces Changes on Renal Vascular Resistance, Vascular Reactivity, and Renin Release in the Isolated Perfused Rat Kidney

Rat kidneys were isolated and perfused with a modified Krebs-Henseleit buffer containing 4% albumin. Perfusate recirculated except during L-platelet activating factor (L-PAF), angiotensin II (ang II), and norepinephrine (NE) infusions. L-PAF caused a dose-dependent decrease in renovascular resistanc...

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Bibliographic Details
Published in:Circulation research 1987-04, Vol.60 (4), p.534-539
Main Authors: Schwertschlag, Ullrich, Scherf, Harald, Gerber, John G, Mathias, Melvin, Nies, Alan S
Format: Article
Language:English
Subjects:
Angiotensin II - pharmacology
Animals
Biological and medical sciences
Blood Vessels - drug effects
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Kidney - metabolism
Male
Norepinephrine - pharmacology
Perfusion
Platelet Activating Factor - pharmacology
Rats
Rats, Inbred Strains
Renal Circulation - drug effects
Renin - metabolism
Vascular Resistance - drug effects
Vasodilation
Vertebrates: urinary system
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Summary:Rat kidneys were isolated and perfused with a modified Krebs-Henseleit buffer containing 4% albumin. Perfusate recirculated except during L-platelet activating factor (L-PAF), angiotensin II (ang II), and norepinephrine (NE) infusions. L-PAF caused a dose-dependent decrease in renovascular resistance (RVR)−6 ± 3% at 10 M, −12 ± 6% at 10 M, −18 ± 3% at 10 M and −20 ± 7% at 10 M. L-PAF increased immunoreactive PGE (iPGE) and thromboxane (iTXB) release into the venous effluent from 2.4 ± 0.2 to 3.9 ± 0.4 ng/min (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.60.4.534