Glyoxalase activities in tumor and non-tumor human urogenital tissues

• Published in: Cancer letters 1995-09, Vol.96 (2), p.189-193
• Main Authors: Di Ilio, Carmine, Angelucci, Stefania, Pennelli, A., Zezza, Andrea, Tenaglia, Raffaele, Sacchetta, Paolo
• Format: Article
• Language: English
• Subjects: Adenoma - enzymology; Adenoma - pathology; Adult; Aged; Biological and medical sciences; Bladder; Carcinoma - enzymology; Carcinoma - pathology; Carcinoma, Renal Cell - enzymology; Carcinoma, Renal Cell - pathology; Carcinoma, Transitional Cell - enzymology; Carcinoma, Transitional Cell - pathology; Female; General aspects (metabolism, cell proliferation, established cell line...); Glyoxalases; Humans; Kidney; Kidney - enzymology; Kidney Neoplasms - enzymology; Kidney Neoplasms - pathology; Lactoylglutathione Lyase - metabolism; Male; Medical sciences; Middle Aged; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - pathology; Reference Values; Seminoma - enzymology; Seminoma - pathology; Testicular Neoplasms - enzymology; Testicular Neoplasms - pathology; Testis; Testis - enzymology; Thiolester Hydrolases - metabolism; Tumor; Tumor cell; Tumors; Urinary Bladder - enzymology; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - pathology; Urinary Tract - enzymology; Urologic Neoplasms - enzymology; Urologic Neoplasms - pathology
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/0304-3835(95)03928-P

Glyoxalase I and glyoxalase II activities have been measured in human tumor and non-tumor samples of 15 kidneys, 15 bladders, 4 testes, 2 adrenals as well as in 4 samples of prostatic adenomas. In all tissues examined glyoxalase I and glyoxalase II activity values varied widely from one patient to another. No significant difference in glyoxalase I activity between the tumor and non-tumor samples was found. When comparison was made between normal and neoplastic tissues of the same patients, glyoxalase I activity was found to be lower in tumor tissues of 10 out of 15 kidneys, and 2 out of 8 bladders and 1 out of 3 testes. A significant ( P < 0.004) decrease of glyoxalase II activity was found only in tumor kidney. The possibility of using the present data to predict the relative sensitivity of human tumor tissues to glyoxalase-related chemotherapy is discussed.