ANTIBACTERIAL ACTIVITIES OF ARBEKACIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC, AGAINST METHICILLIN-CEPHEM-RESISTANT STAPHYLOCOCCUS AUREUS

The in vitro and in vivo antibacterial activities of a new aminoglycoside antibiotic, arbekacin (HBK), against methicillin-cephem-resistant Staphylococcus aureus (MRSA) were compared with those of gentamicin (GM), netilmicin (NTL) and amikacin (AMK). The results obtained were summarized as follows:...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1987/02/25, Vol.40(2), pp.349-356
Main Authors: WATANABE, TADAHIRO, GOI, HITOSHI, HARA, TETSURO, SUGANO, TOSHIE, TANAKA, YOSHIKO, KAZUNO, YUZO, MATSUHASHI, YUJI, YAMAMOTO, HARUO, YOKOTA, TAKESHI
Format: Article
Language:Japanese
Subjects:
Abscess - prevention & control
Aminoglycosides - pharmacology
Aminoglycosides - therapeutic use
Animals
Anti-Bacterial Agents
Bacterial Infections - prevention & control
Cephalosporins - pharmacology
Dibekacin - analogs & derivatives
Dibekacin - pharmacology
Dibekacin - therapeutic use
Kanamycin - analogs & derivatives
Male
Methicillin - pharmacology
Mice
Penicillin Resistance
Skin Diseases - prevention & control
Staphylococcus aureus - drug effects
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Summary:The in vitro and in vivo antibacterial activities of a new aminoglycoside antibiotic, arbekacin (HBK), against methicillin-cephem-resistant Staphylococcus aureus (MRSA) were compared with those of gentamicin (GM), netilmicin (NTL) and amikacin (AMK). The results obtained were summarized as follows: 1. Compared to other aminoglycoside antibiotics, HBK had the highest antibacterial activities against clinically isolated MRSA (46 strains). 2. Therapeutic effects of HBK against experimental systemic infections with MRSA in mice, were superior to those of GM, NTL and AMK. The ED50's of GM, NTL and AMK were more than 2 mg/mouse. 3. Therapeutic effects of HBK against experimental subcutaneous infections with MRSA in mice were also superior to those of GM, NTL and AMK.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.40.349