Phagolysosome Formation by Polymorphonuclear Neutrophilic Leukocytes After Ingestion of Escherichia coli that Express Type 1 Pili

Escherichia coli that express type 1 pili T1P super(+) E. coli) adhere to human polymorphonuclear neutrophilic leukocytes (PMNLs) and are subsequently ingested and killed in the absence of serum opsonins. Such nonopsonic activation of PMNLs, if of a sufficient magnitude, might explain why these bact...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-07, Vol.156 (1), p.229-233
Main Authors: Goetz, Matthew Bidwell, Kuriyama, Steve M., Silverblatt, Fredric J.
Format: Article
Language:English
Subjects:
Adhesiveness
Bacteria
Bacteriology
Biological and medical sciences
Blood Bactericidal Activity
Chemotherapy
Concise Laboratory and Clinical Comunication
Crystals
Escherichia coli
Escherichia coli - immunology
Fimbriae, Bacterial - physiology
Fundamental and applied biological sciences. Psychology
Humans
Ingestion
Microbiology
Neutrophils
Neutrophils - immunology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Peroxidase - analysis
Phagocytes
Phagocytosis
Phagosomes
Phagosomes - enzymology
Phagosomes - physiology
Photomicrographs
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Summary:Escherichia coli that express type 1 pili T1P super(+) E. coli) adhere to human polymorphonuclear neutrophilic leukocytes (PMNLs) and are subsequently ingested and killed in the absence of serum opsonins. Such nonopsonic activation of PMNLs, if of a sufficient magnitude, might explain why these bacteria have been epidemiologically linked with superficial, rather than invasive, infections of the urinary tract. The authors report the results of studies in which they compared the rate at which PMNLs ingest and kill type 1 pili-expressing and nonexpressing (T1P super(-)) phase variants of a single strain of E. coli).
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/156.1.229