Sarcomatous degeneration in Paget's bone disease

The authors report 12 cases (8 men and 4 women) of sarcomatous degeneration in Paget's bone disease, with an average age of 72.3 years. Sarcomatous degeneration occurred often in polyostotic Paget's disease, and osteitis deformans was seen in 4 cases. Femur and pelvis were the most affecte...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1987-01, Vol.113 (4), p.392-399
Main Authors: SERET, P, BASLE, M. F, REBEL, A, RENIER, J. C, SAINT-ANDRE, J. P, BERTRANS, G, AUDRAN, M
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - etiology
Bone Neoplasms - pathology
Diseases of the osteoarticular system
Female
Fibrosarcoma - diagnostic imaging
Fibrosarcoma - etiology
Fibrosarcoma - pathology
Humans
Male
Medical sciences
Microscopy, Electron
Middle Aged
Osteitis Deformans - complications
Osteitis Deformans - diagnostic imaging
Osteitis Deformans - pathology
Osteoporosis. Osteomalacia. Paget disease
Osteosarcoma - diagnostic imaging
Osteosarcoma - etiology
Osteosarcoma - pathology
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The authors report 12 cases (8 men and 4 women) of sarcomatous degeneration in Paget's bone disease, with an average age of 72.3 years. Sarcomatous degeneration occurred often in polyostotic Paget's disease, and osteitis deformans was seen in 4 cases. Femur and pelvis were the most affected bones. Pain was a constant feature, whereas tumefaction and fracture were less common. Osteolytic lesions were more frequent than condensed or mixed lesions and radiological signs of malignancy were usually found. Seven cases were histologically classified as osteogenic sarcoma and 3 cases as fibrosarcoma. Electron microscopy was performed on 2 osteogenic sarcomas and in 1 case revealed microcylindrical inclusions in Pagetic osteoclasts and in multinucleated giant tumor cells, but none in mononucleated tumor cells. The average survival time for the patients in this study was only 4.5 months.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF00397726