Viremia, Fecal Shedding, and IgM and IgG Responses in Patients with Hepatitis E

Viremia, fecal shedding and antibody responses to hepatitis E virus (HEV) infections are poorly understood. To better characterize HEV infections, these responses were examined in 67 patients with acute markers for hepatitis E who were admitted to the Infectious Disease Hospital in Kathmandu, Nepal...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-10, Vol.172 (4), p.927-933
Main Authors: Clayson, Edward T., Myint, Khin Saw Aye, Snitbhan, Rapin, Vaughn, David W., Innis, Bruce L., Chan, Lily, Cheung, Peter, Shrestha, Mrigendra P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alanine Transaminase - blood
Antibodies
Biological and medical sciences
Diseases
Enzyme-Linked Immunosorbent Assay
Feces - virology
Female
Hepatitis
Hepatitis Antibodies - blood
Hepatitis E
Hepatitis E - diagnosis
Hepatitis E - epidemiology
Hepatitis E - immunology
Hepatitis E - virology
Hepatitis E virus
Human viral diseases
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Infections
Infectious diseases
Major Articles
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
RNA
RNA, Viral - blood
Thailand - epidemiology
Time Factors
Viral diseases
Viral hepatitis
Viremia
Virus Shedding
Viruses
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Description
Summary:Viremia, fecal shedding and antibody responses to hepatitis E virus (HEV) infections are poorly understood. To better characterize HEV infections, these responses were examined in 67 patients with acute markers for hepatitis E who were admitted to the Infectious Disease Hospital in Kathmandu, Nepal in 1993. A single stool and multiple sera from each patient were examined using polymerase chain reaction to detect HEV RNA. Sera were also examined for antibodies to HEV. Viremia, fecal shedding, and IgM and IgG to HEV were detected in 93%, 70%, 79%, and 87% of 67 patients, respectively. Viremia or fecal shedding (or both) were detected in 14 patients from whom IgM and IgG to HEV were not detected. Viremia lasted at least 2 weeks in nearly all subjects and at least 39 days in 1 subject. Our results suggest that viremia is a common occurrence in patients infected with HEV.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/172.4.927