Medroxyprogesterone acetate plasma pharmacokinetics after intravenous administration in rabbits

Medroxyprogesterone acetate (MAP) plasma pharmacokinetics was followed up in a total of 30 New Zealand rabbits after i.v. administration (0.1, 0.5, and 1.0 mg/kg) of either an aqueous suspension or a homogeneous solution of the drug in dimethylsulphoxide (DMSO). A well-defined triphasic decay of MAP...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1987-01, Vol.19 (4), p.311-314
Main Authors: PANNUTI, F, CAMAGGI, C. M, STROCCHI, E, COMPARSI, R
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Chromatography, Gas
Dimethyl Sulfoxide
Female
General aspects
Kinetics
Male
Medical sciences
Medroxyprogesterone - administration & dosage
Medroxyprogesterone - analogs & derivatives
Medroxyprogesterone - metabolism
Medroxyprogesterone Acetate
Pharmacology. Drug treatments
Rabbits
Solutions
Suspensions
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Summary:Medroxyprogesterone acetate (MAP) plasma pharmacokinetics was followed up in a total of 30 New Zealand rabbits after i.v. administration (0.1, 0.5, and 1.0 mg/kg) of either an aqueous suspension or a homogeneous solution of the drug in dimethylsulphoxide (DMSO). A well-defined triphasic decay of MAP plasma levels was noticeable in the animals treated with DMSO solutions. A delayed concentration peak was often present when aqueous suspensions were used, so if is not feasible to fit the experiment with simple polyexponential equations. Model-independent pharmacokinetic analysis (statistical moment theory) revealed a significant dependence of plasma clearance and mean residence time on the dose administered in both conditions.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00261479