Skeletal muscle phosphorylase kinase catalytic subunit mRNAs are expressed in heart tissue but not in liver

A cDNA encoding the skeletal muscle phosphorylase kinase catalytic subunit gamma has been isolated and sequenced. It contains 57 nucleotides of 5′ nontranslated sequence, the entire coding sequence, and 1004 nucleotides of 3′ nontranslated sequence. Probes derived from this gamma-cDNA were used to i...

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Bibliographic Details
Published in:The Journal of biological chemistry 1987-06, Vol.262 (18), p.8799-8805
Main Authors: Bender, P K, Emerson, C P
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
DNA - metabolism
Fundamental and applied biological sciences. Psychology
Gene expression
Genes
Liver - enzymology
Macromolecular Substances
Mice
Mice, Inbred ICR
Molecular and cellular biology
Molecular genetics
Muscles - enzymology
Myocardium - enzymology
Organ Specificity
Phosphorylase Kinase - genetics
Protein Biosynthesis
RNA, Messenger - genetics
Transcription, Genetic
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Description
Summary:A cDNA encoding the skeletal muscle phosphorylase kinase catalytic subunit gamma has been isolated and sequenced. It contains 57 nucleotides of 5′ nontranslated sequence, the entire coding sequence, and 1004 nucleotides of 3′ nontranslated sequence. Probes derived from this gamma-cDNA were used to investigate the expression of gamma-messages in liver, heart, and skeletal muscle tissues. The results demonstrate that the gamma-mRNAs expressed in heart tissue are homologous to the skeletal muscle gamma-mRNAs. However, in liver tissue, no homologous gamma-mRNAs were detected. The implications of these results for understanding gamma-isoform expression and the possibility of a liver-specific gamma-gene are discussed.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)47485-6