Bactericidal Activity for Neisseria meningitidis in Properdin-Deficient Sera

We investigated serum bactericidal reactions against Neisseria meningitidis (serogroups A, B, C, D, Y, W-135, 29E, X, and Z) in the sera of two healthy adults with properdin deficiency. Bactericidal reactions mediated via the classic complement pathway (unchelated system) were not impaired in proper...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-07, Vol.156 (1), p.107-112
Main Authors: Söderström, C., Braconier, J. H., Danielsson, D., Sjöholm, A. G.
Format: Article
Language:English
Subjects:
Adults
Antibodies
Antibodies, Bacterial - analysis
Antibodies, Bacterial - immunology
Antigens
Bacteria
Bacteriology
Biological and medical sciences
Blood Bactericidal Activity
Complement Pathway, Alternative
Complement Pathway, Classical
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin G - immunology
Infections
Infectious diseases
Male
Microbiology
Neisseria meningitidis
Neisseria meningitidis - immunology
Original Articles
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Polysaccharides
Properdin - deficiency
Properdin - pharmacology
Rum
Vaccination
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Summary:We investigated serum bactericidal reactions against Neisseria meningitidis (serogroups A, B, C, D, Y, W-135, 29E, X, and Z) in the sera of two healthy adults with properdin deficiency. Bactericidal reactions mediated via the classic complement pathway (unchelated system) were not impaired in properdin-deficient serum. The properdin-deficient sera supported alternative pathway-mediated killing (Mg++EGTA-chelated system) of some, but not all, of the strains investigated. Vaccination of the properdin-deficient individuals with serogroup A and C polysaccharide clearly increased the concentrations of antibody to meningococci. At least some of the antibodies induced by vaccination supported the bactericidal activity of properdin-deficient serum. Some antibodies to meningococci, probably of the IgM class, promoted alternative pathway-mediated bactericidal reactions in the absence of properdin. By contrast, presensitizing meningococci with IgG enhanced the alternative pathway-mediated reactions, but this was strictly a properdin-dependent effect.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/156.1.107