Echocardiographic characterization of left ventricular adaptation in a genetically determined heart failure rat model

This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure—prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hyper...

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Bibliographic Details
Published in:The American heart journal 1995-10, Vol.130 (4), p.806-811
Main Authors: Haas, Garrie J., McCune, Sylvia A., Brown, Douglas M., Cody, Robert J.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Biological and medical sciences
Cardiovascular system
Echocardiography
Heart Ventricles - pathology
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Myocardium - pathology
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Rats, Inbred WKY
Rats, Sprague-Dawley
Space life sciences
Ultrasonic investigative techniques
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Summary:This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure—prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hypertensive rats (SHR) were compared. Wistar-Kyoto and Sprague-Dawley strains served as the normotensive control group. SHHF rats had significantly greater left ventricular mass than did rats in the normotensive control group. Although left ventricular mass was not different between SHHF and SHR, significant differences were seen in the pattern of left ventricular remodeling as determined by relative wall thickness. These differences in left ventricular remodeling may explain the earlier development of heart failure in SHHF. The different patterns of left ventricular hypertrophy in SHHF and SHR suggests that heart failure in SHHF is not mediated by hypertension alone.
ISSN:0002-8703
1097-6744
DOI:10.1016/0002-8703(95)90081-0