Effects of an every other day rapid kindling procedure in prenatally protein malnourished rats

• Published in: Brain research 1995-06, Vol.682 (1), p.35-40
• Main Authors: Shultz, Penny L., Tonkiss, John, Morgane, Peter J., Bronzino, Joseph D., Galler, Janina R.
• Format: Article
• Language: English
• Subjects: Animal Nutritional Physiological Phenomena; Animals; Biological and medical sciences; Electrodes, Implanted; Female; Fully kindled state; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hippocampal formation; Inhibition; Kindling, Neurologic - physiology; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal protein malnutrion; Protein-Energy Malnutrition - physiopathology; Rapid kindling; Rat; Rats; Rats, Sprague-Dawley; Seizures - physiopathology; Time Factors
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/0006-8993(95)00314-G

Prenatally protein malnourished ( 625) rats have been reported to require significantly more stimulations to attain a stage 5 seizure than well-nourished controls ( 2525) when using either a traditional or rapid every day, kindling procedure. In the present study, a rapid kindling procedure was utilized where both prenatally malnourished and control rats received every other day perforant path kindling (50 Hz, 10 s train) 12 times a day at 5-min intervals. Using this procedure, stage 5 seizures and a fully kindled state were attained in both nutritional groups at approximately the same rate. It is postulated that it is the every other day component of the present procedure which overcomes seizure-induced inhibition in the 625 subjects, thereby allowing them to attain stage 5 seizures at the same rate as controls.