Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

Normal haematopoietic cell regulation involves interaction between marrow stromal cells and haematopoietic progenitor cells which may be facilitated by specific recognition and adhesion. Some leukaemogenic events might produce a selective growth advantage by altering this regulatory network, possibl...

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Bibliographic Details
Published in:Nature (London) 1987-07, Vol.328 (6128), p.342-344
Main Authors: Gordon, M. Y, Dowding, C. R, Riley, G. P, Goldman, J. M, Greaves, M. F
Format: Article
Language:English
Subjects:
Adhesion
Adhesives
Bone Marrow - pathology
Bone Marrow Cells
Bones
Cell Adhesion
Cells, Cultured
Cellular biology
chronic myeloid leukemia
hematopoiesis
Hematopoietic Stem Cells - cytology
Humans
Leukemia
Leukemia, Myeloid - blood
Leukemia, Myeloid - pathology
man
Medical research
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Summary:Normal haematopoietic cell regulation involves interaction between marrow stromal cells and haematopoietic progenitor cells which may be facilitated by specific recognition and adhesion. Some leukaemogenic events might produce a selective growth advantage by altering this regulatory network, possibly by diminishing the capacities of cells to adhere to stromal elements. Using an in vitro culture system which allows investigation of adhesion to stromal layers and subsequent colony formation by blast colony-forming cells (B1-CFC) in normal marrow and Ph+ chronic myeloid leukaemic (CML) blood, we compared the adhesive properties of normal and malignant progenitor cells. We present evidence that altered adhesive interactions between primitive progenitor cells and marrow stromal cells occur in CML.
ISSN:0028-0836
1476-4687
DOI:10.1038/328342a0