METABOLISM OF PEPTIDE DRUGS BY THE MICROORGANISMS IN RAT CECAL CONTENTS

The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also rapidly degraded in supernatant, while we found fe...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1995/06/15, Vol.18(6), pp.929-931
Main Authors: TOZAKI, Hideyuki, EMI, Yasuharu, HORISAKA, Eri, FUJITA, Takuya, YAMAMOTO, Akira, MURANISHI, Shozo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
calcitonin
Calcitonin - metabolism
Cecum - metabolism
Cecum - microbiology
colon-specific drug delivery
General pharmacology
Half-Life
insulin
Insulin - metabolism
Medical sciences
microorganism
Peptides - metabolism
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Rats
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Summary:The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also rapidly degraded in supernatant, while we found few degradation products of insulin. These findings suggest that care should be taken to metabolize the peptide drugs by microorganisms when they are administered to the large intestine for colon-specific drug delivery.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.18.929