An eight-way variant t(15;17) in acute promyelocytic leukemia elucidated using fluorescence in situ hybridization

A complex eight-way translocation was identified, with the aid of fluorescence in situ hybridization (FISH), in a patient diagnosed as having acute promyelocytic leukemia (APL). The balanced translocation was defined as 46,XY,t(1;6;7;6;17;15;12;3)(p22;q27;p15;q13;q21;q22;q13;p13), which includes a d...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1995-09, Vol.83 (2), p.136-139
Main Authors: Hiorns, Lynne R., John Swansbury, G., Catovsky, Daniel
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Promyelocytic, Acute - genetics
Leukemia, Promyelocytic, Acute - therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Translocation, Genetic
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Summary:A complex eight-way translocation was identified, with the aid of fluorescence in situ hybridization (FISH), in a patient diagnosed as having acute promyelocytic leukemia (APL). The balanced translocation was defined as 46,XY,t(1;6;7;6;17;15;12;3)(p22;q27;p15;q13;q21;q22;q13;p13), which includes a der(15) chromosome consistent with the der(15) chromosome of the t(15;17)(q22;q21) typically found in APL. The patient was treated with all-trans retinoic acid (ATRA) and had a clinical course typical of the disease, which is currently in remission after an autologous bone marrow transplant. The other structural rearrangements appeared to have little effect on the biology of the neoplasia.
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(95)00048-T