Vascular complications after pediatric liver transplantation

• Published in: Journal of pediatric surgery 1995-08, Vol.30 (8), p.1122-1126
• Main Authors: Lallier, Michel, St-Vil, Dickens, Dubois, Josée, Paradis, Khazal, Laberge, Jean-Martin, Bensoussan, AriéL., Guttman, Frank M., Blanchard, Herve
• Format: Article
• Language: English
• Subjects: Anastomosis, Surgical - adverse effects; Anastomosis, Surgical - methods; Antibodies, Anticardiolipin - analysis; Aorta - injuries; Aorta - surgery; Biological and medical sciences; Body Weight; Cause of Death; Child; Child, Preschool; Follow-Up Studies; Graft Survival; Hepatic Artery - surgery; Humans; Hypertension, Portal - surgery; Incidence; Liver Transplantation - adverse effects; Liver Transplantation - methods; Liver, biliary tract, pancreas, portal circulation, spleen; Medical sciences; Portal Vein - surgery; Reoperation; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survival Rate; Thrombectomy; Thrombosis - etiology; Thrombosis - surgery
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1016/0022-3468(95)90002-0

From February 1986 to July 1994, 81 hepatic transplantations were performed in 73 children, with an oveall patient survival rate of 83%. Forty-two patients received whole-liver grafts (WLG) and 39 had reduced-size grafts (RSG). The mean patient weight was 19.7 kg, with 29 patients weighing less than 10 kg. Seventeen vascular complications (21%) occurred in 13 children: 8 (10%) had hepatic artery thrombosis (HAT), 5 (6%) had portal vein thrombosis (PVT), 1 had both HAT and PVT (1%), and 3 (4%) had aortic conduit perforation (ACP). There was no significant difference in the incidence of HAT between RSG (5%) and WLG (14%) or between children weighing less than 10 kg (10%) and those weighing more than 10 kg (10%). The site of arterial reconstruction, end-to-end to the recipient common hepatic artery or end-to-side to the infrarenal aorta, had no significant effect on the occurrence of HAT (7% v 8%), but HAT occurred in 2 of 6 cases (33%) in which an aortic conduit was used. PVT documented in 5 cases (6%) was associated with technical complications (2), preduodenal portal vein (2), and a circulating cardiolipid antibody (1), and required thrombectomy, with no graft loss. Combined HAT and PVT was found in one patient 2 years postretransplantation for HAT. Although graft function is normal, portal hypertension persists. The aortic conduit, used in six patients, led to arterial perforation (3), HAT (2), and death (2). Of the 8 cases of HAT, 1 was diagnosed during autopsy and 7 occurred within 30 days and required retransplantation (6) or thrombectomy with rearterialization (1). Anomalous arterial supply, found in 14 donor grafts (17%), was associated with 4 occurrences of HAT (29%) and 6 deaths. Vascular complications, particularly in children weighing less than 10 kg, have decreased with the liberal use of RSG in pediatric liver transplantation, but aortic conduit, anomalous arterial supply in the donor graft, and technical complications remained significant causes of graft loss and patient death.