Structural Organization and Mapping of the Human TCF11 Gene

We recently cloned human cDNA representing several mRNA isoforms of human TCF11, a transcription factor of the basic-region, leucine-zipper (bZIP) family located on chromosome 17q22 as well as a genomic clone of this gene. We have now determined the complete genomic organization of the TCF11 gene, w...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1995-05, Vol.27 (2), p.237-244
Main Authors: Luna, Luisa, Skammelsrud, Nina, Johnsen, Øyvind, Abel, Kenneth J., Weber, Barbara L., Prydz, Hans, Kolstø, Anne-Brit
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Blotting, Southern
Caenorhabditis - genetics
Caenorhabditis elegans Proteins
Chromosome Mapping
DNA Probes
DNA, Complementary - chemistry
DNA-Binding Proteins
Exons
Fundamental and applied biological sciences. Psychology
Genes. Genome
Helminth Proteins - genetics
Humans
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
NF-E2-Related Factor 1
Sequence Homology
Transcription Factors - genetics
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Summary:We recently cloned human cDNA representing several mRNA isoforms of human TCF11, a transcription factor of the basic-region, leucine-zipper (bZIP) family located on chromosome 17q22 as well as a genomic clone of this gene. We have now determined the complete genomic organization of the TCF11 gene, which consists of 9 exons distributed over 15 kb of genomic DNA. Pulsed-field gel electrophoresis was used to construct a physical map around TCF11, to characterize a 450-kb YAC clone that contains the gene, and to link TCF11 physically to BTR, a marker on chromosome 17.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1995.1037