Schizo-affective disorders: bipolar-unipolar subtyping: Natural history variables: a discriminant analysis approach

In view of tackling the problem of heterogeneity among the schizo-affectives, methods of univariate and multivariate statistical analysis (canonical discriminant analysis) were applied to the sociodemographic and natural history variables of four groups of affective disorder patients from the NIMH C...

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Bibliographic Details
Published in:Journal of affective disorders 1987-05, Vol.12 (3), p.223-232
Main Authors: Van Eerdewegh, M.M., Van Eerdewegh, P., Coryell, W., Clayton, P.J., Endicott, J., Koepke, J., Rochberg, N.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Bipolar
Bipolar Disorder - classification
Depressive Disorder - classification
Discriminant analysis
DSM-III
Humans
Medical sciences
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychotic Disorders - classification
Psychotic Disorders - diagnosis
Psychotic Disorders - epidemiology
Schizo-affective
Schizo-depression
Schizo-mania
Socioeconomic Factors
Syndrome
Unipolar
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Summary:In view of tackling the problem of heterogeneity among the schizo-affectives, methods of univariate and multivariate statistical analysis (canonical discriminant analysis) were applied to the sociodemographic and natural history variables of four groups of affective disorder patients from the NIMH Collaborative Study on the Psychobiology of Depression Clinical section: the schizo-bipolar (SBP, n = 45), the schizo-unipolar (SUP, n = 30), the bipolar I (BP, n = 159) and the primary unipolar depressed (UP, n = 387) defined by Research Diagnostic Criteria. Two dimensions were identified among the four groups of ‘affective’ patients: the ‘bipolar’ and the ‘schizophrenic’ dimensions. Theyprovided highly significant discrimination among the means of the four groups but were not very accurate in predicting group membership. The ‘bipolar’ dimension separates the UP from the BP and SBP, the SUP taking some intermediate value. The ‘schizophrenic’ dimension separates the BP and UP from the SUP, the SBP being intermediate. The two groups with the most similarities were the SBP and BP. The group with the most heterogeneity was the SUP, sharing similarities with the UP and SBP mostly. These conclusions are supported by results of familial aggregation on the same group of patients.
ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(87)90031-0