Loss of the chromosomal region 10q23-25 in prostate cancer

Loss of the chromosomal region 10q23-25 is a frequent event in the progression of prostate adenocarcinoma. A candidate tumor suppressor gene from this region, Mxi1 at 10q25, has recently been shown to be mutated in a small number of prostate tumors. To more strictly define those regions of 10q loss...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1995-11, Vol.55 (21), p.4800-4803
Main Authors: GRAY, I. C, PHILLIPS, S. M. A, LEE, S. J, NEOPTOLEMOS, J. P, WEISSENBACH, J, SPURR, N. K
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Biological and medical sciences
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 10 - genetics
DNA, Neoplasm - analysis
DNA, Neoplasm - genetics
DNA, Satellite - analysis
DNA, Satellite - genetics
DNA-Binding Proteins - genetics
Fluorescence
Genes, Tumor Suppressor
Genetic Markers
Heterozygote
Humans
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Mutation
Neoplasm Staging
Nephrology. Urinary tract diseases
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Transcription Factors
Tumor Suppressor Proteins
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:Loss of the chromosomal region 10q23-25 is a frequent event in the progression of prostate adenocarcinoma. A candidate tumor suppressor gene from this region, Mxi1 at 10q25, has recently been shown to be mutated in a small number of prostate tumors. To more strictly define those regions of 10q loss that are likely to be involved in tumor advancement, we have constructed a detailed deletion map spanning 10q23-25 that incorporates Mxi1. Sixty-two % (23 of 37) of tumors analyzed exhibited some degree of 10q23-25 loss. Our data suggest the presence of a prostate tumor suppressor gene(s) near the 10q23-24 boundary, which was deleted in the overwhelming majority (22 of 23) of tumors showing loss. In contrast, specific loss of Mxi1, as opposed to loss of other 10q23-25 regions or of the entire region, was observed in only 1 of 23 tumors and was accompanied by loss of markers at the 10q23-24 boundary. Furthermore, we failed to detect any mutations in Mxi1 in those tumors showing Mxi1-associated marker loss by either single-strand conformation polymorphism analysis or direct DNA sequencing.
ISSN:0008-5472
1538-7445