The normal pituitary examined with positron emission tomography and (methyl-11C)-L-methionine and (methyl-11C)-D-methionine

Four patients with radiologically normal pituitary gland were examined with positron emission tomography after the administration of (methyl-11C)-L-methionine. On a following day the examination was repeated with (methyl-11C)-D-methionine. The accumulation rate of L-methionine in the pituitary was m...

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Bibliographic Details
Published in:Neuroradiology 1987-05, Vol.29 (3), p.221-225
Main Authors: BERGSTROM, M, MUHR, C, ERICSON, K, LUNDQVIST, H, LILJA, A, ERIKSSON, L, BLOMQUIST, G, LANGSTROM, B, JOHNSTROM, P
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain Neoplasms - diagnostic imaging
Carbon Radioisotopes
Endocrine glands. Genital system. Mammary gland
Female
Glioma - diagnostic imaging
Humans
Investigative techniques, diagnostic techniques (general aspects)
Kinetics
Medical sciences
Methionine - analogs & derivatives
Pituitary Gland - diagnostic imaging
Radionuclide investigations
Stereoisomerism
Tomography, Emission-Computed - methods
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Summary:Four patients with radiologically normal pituitary gland were examined with positron emission tomography after the administration of (methyl-11C)-L-methionine. On a following day the examination was repeated with (methyl-11C)-D-methionine. The accumulation rate of L-methionine in the pituitary was measured, giving a value that was about twice that of normal brain tissue. The accumulation rate of D-methionine in the pituitary was almost a factor of 10 lower than that of L-methionine. In the normal brain tissue that ratio was 2.3. The study clearly indicates that the methionine uptake in the pituitary is stereospecific. 11C-D-methionine is freely distributed in the tissue without entrapment, whereas 11C-L-methionine is irreversibly bound. It is concluded that PET with 11C-L-methionine can be used to study amino acid utilization in the pituitary.
ISSN:0028-3940
1432-1920
DOI:10.1007/BF00451757