DNA Polymorphism at the ABO Locus in the Chinese Population of Hong Kong

DNA polymorphism at the ABO locus was investigated using denaturing gradient gel electrophoresis of polymerase-chain-reaction-amplified DNA products from 315 healthy individuals of the Chinese population of Hong Kong. Five different alleles were identified: ABO*A1, O2, A1, A2 and B1. The ABO*A2 is a...

Full description

Saved in:
Bibliographic Details
Published in:Human heredity 1995-09, Vol.45 (5), p.266-271
Main Authors: Yip, S.P., Yow, C.M.N., Lewis, W.H.P.
Format: Article
Language:English
Subjects:
ABO Blood-Group System - genetics
Adult
Alleles
Base Sequence
Biological and medical sciences
China - ethnology
DNA - blood
DNA - genetics
DNA Primers
Europe - ethnology
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Hong Kong
Human
Humans
Molecular Sequence Data
Original Paper
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic
Population genetics, reproduction patterns
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c424t-c26f68220748dd297646ff48b3c749f12e7eae3d60994c6c96138ac5789a64b13
cites
container_end_page 271
container_issue 5
container_start_page 266
container_title Human heredity
container_volume 45
creator Yip, S.P.
Yow, C.M.N.
Lewis, W.H.P.
description DNA polymorphism at the ABO locus was investigated using denaturing gradient gel electrophoresis of polymerase-chain-reaction-amplified DNA products from 315 healthy individuals of the Chinese population of Hong Kong. Five different alleles were identified: ABO*A1, O2, A1, A2 and B1. The ABO*A2 is a new allele not previously reported in the literature. The allele frequencies found were 0.3698 for O1, 0.2508 for O2, 0.1952 for A1, 0.0159 for A2, and 0.1683 for B1. The Chinese population being investigated was in Hardy-Weinberg equilibrium. The genotyping method identifies many more alleles in the ABO locus and thus makes it a more useful genetic marker in linkage analysis, paternity testing and individualization in forensic work than when the locus is genotyped using conventional DNA-based methods or phenotyped using serological methods.
doi_str_mv 10.1159/000154311
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_77619199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77619199</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-c26f68220748dd297646ff48b3c749f12e7eae3d60994c6c96138ac5789a64b13</originalsourceid><addsrcrecordid>eNpt0EFPwyAUB3BiNHNOD941IdGYeKgCpVCOc05rXJwHPTeMwlZtS4X2sG9v55qevEB4_1_eIw-Ac4zuMI7EPUIIRzTE-ACMMSVhgBAjh2C8qwcRi8gxOPH-q3vGiIcjMOKRQDyKxyB5fJvCd1tsS-vqTe5LKBvYbDScPizhwqrWw7z6K8w2eaW97nDdFrLJbQWtgYmt1vC1O07BkZGF12f9PQGfT_OPWRIsls8vs-kiUJTQJlCEGRYTgjiNs4wIzigzhsarUHEqDCaaa6nDjCEhqGJKMBzGUkU8FpLRFQ4n4Gbft3b2p9W-ScvcK10UstK29SnnDAssRAdv91A5673TJq1dXkq3TTFKd1tLh6119rJv2q5KnQ2yX1OXX_e59EoWxslK5X5gIcM72bGrPfuWbq3dkCfJfD8orTPTqYt_Vf-XX9F_hYM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77619199</pqid></control><display><type>article</type><title>DNA Polymorphism at the ABO Locus in the Chinese Population of Hong Kong</title><source>JSTOR Archival Journals and Primary Sources Collection</source><creator>Yip, S.P. ; Yow, C.M.N. ; Lewis, W.H.P.</creator><creatorcontrib>Yip, S.P. ; Yow, C.M.N. ; Lewis, W.H.P.</creatorcontrib><description>DNA polymorphism at the ABO locus was investigated using denaturing gradient gel electrophoresis of polymerase-chain-reaction-amplified DNA products from 315 healthy individuals of the Chinese population of Hong Kong. Five different alleles were identified: ABO*A1, O2, A1, A2 and B1. The ABO*A2 is a new allele not previously reported in the literature. The allele frequencies found were 0.3698 for O1, 0.2508 for O2, 0.1952 for A1, 0.0159 for A2, and 0.1683 for B1. The Chinese population being investigated was in Hardy-Weinberg equilibrium. The genotyping method identifies many more alleles in the ABO locus and thus makes it a more useful genetic marker in linkage analysis, paternity testing and individualization in forensic work than when the locus is genotyped using conventional DNA-based methods or phenotyped using serological methods.</description><identifier>ISSN: 0001-5652</identifier><identifier>EISSN: 1423-0062</identifier><identifier>DOI: 10.1159/000154311</identifier><identifier>PMID: 7590758</identifier><identifier>CODEN: HUHEAS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>ABO Blood-Group System - genetics ; Adult ; Alleles ; Base Sequence ; Biological and medical sciences ; China - ethnology ; DNA - blood ; DNA - genetics ; DNA Primers ; Europe - ethnology ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Hong Kong ; Human ; Humans ; Molecular Sequence Data ; Original Paper ; Phenotype ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Population genetics, reproduction patterns</subject><ispartof>Human heredity, 1995-09, Vol.45 (5), p.266-271</ispartof><rights>1995 S. Karger AG, Basel</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-c26f68220748dd297646ff48b3c749f12e7eae3d60994c6c96138ac5789a64b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=3617590$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7590758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yip, S.P.</creatorcontrib><creatorcontrib>Yow, C.M.N.</creatorcontrib><creatorcontrib>Lewis, W.H.P.</creatorcontrib><title>DNA Polymorphism at the ABO Locus in the Chinese Population of Hong Kong</title><title>Human heredity</title><addtitle>Hum Hered</addtitle><description>DNA polymorphism at the ABO locus was investigated using denaturing gradient gel electrophoresis of polymerase-chain-reaction-amplified DNA products from 315 healthy individuals of the Chinese population of Hong Kong. Five different alleles were identified: ABO*A1, O2, A1, A2 and B1. The ABO*A2 is a new allele not previously reported in the literature. The allele frequencies found were 0.3698 for O1, 0.2508 for O2, 0.1952 for A1, 0.0159 for A2, and 0.1683 for B1. The Chinese population being investigated was in Hardy-Weinberg equilibrium. The genotyping method identifies many more alleles in the ABO locus and thus makes it a more useful genetic marker in linkage analysis, paternity testing and individualization in forensic work than when the locus is genotyped using conventional DNA-based methods or phenotyped using serological methods.</description><subject>ABO Blood-Group System - genetics</subject><subject>Adult</subject><subject>Alleles</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>China - ethnology</subject><subject>DNA - blood</subject><subject>DNA - genetics</subject><subject>DNA Primers</subject><subject>Europe - ethnology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Hong Kong</subject><subject>Human</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Original Paper</subject><subject>Phenotype</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Population genetics, reproduction patterns</subject><issn>0001-5652</issn><issn>1423-0062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNpt0EFPwyAUB3BiNHNOD941IdGYeKgCpVCOc05rXJwHPTeMwlZtS4X2sG9v55qevEB4_1_eIw-Ac4zuMI7EPUIIRzTE-ACMMSVhgBAjh2C8qwcRi8gxOPH-q3vGiIcjMOKRQDyKxyB5fJvCd1tsS-vqTe5LKBvYbDScPizhwqrWw7z6K8w2eaW97nDdFrLJbQWtgYmt1vC1O07BkZGF12f9PQGfT_OPWRIsls8vs-kiUJTQJlCEGRYTgjiNs4wIzigzhsarUHEqDCaaa6nDjCEhqGJKMBzGUkU8FpLRFQ4n4Gbft3b2p9W-ScvcK10UstK29SnnDAssRAdv91A5673TJq1dXkq3TTFKd1tLh6119rJv2q5KnQ2yX1OXX_e59EoWxslK5X5gIcM72bGrPfuWbq3dkCfJfD8orTPTqYt_Vf-XX9F_hYM</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Yip, S.P.</creator><creator>Yow, C.M.N.</creator><creator>Lewis, W.H.P.</creator><general>Karger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>DNA Polymorphism at the ABO Locus in the Chinese Population of Hong Kong</title><author>Yip, S.P. ; Yow, C.M.N. ; Lewis, W.H.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-c26f68220748dd297646ff48b3c749f12e7eae3d60994c6c96138ac5789a64b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>ABO Blood-Group System - genetics</topic><topic>Adult</topic><topic>Alleles</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>China - ethnology</topic><topic>DNA - blood</topic><topic>DNA - genetics</topic><topic>DNA Primers</topic><topic>Europe - ethnology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>Hong Kong</topic><topic>Human</topic><topic>Humans</topic><topic>Molecular Sequence Data</topic><topic>Original Paper</topic><topic>Phenotype</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Population genetics, reproduction patterns</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yip, S.P.</creatorcontrib><creatorcontrib>Yow, C.M.N.</creatorcontrib><creatorcontrib>Lewis, W.H.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yip, S.P.</au><au>Yow, C.M.N.</au><au>Lewis, W.H.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA Polymorphism at the ABO Locus in the Chinese Population of Hong Kong</atitle><jtitle>Human heredity</jtitle><addtitle>Hum Hered</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>45</volume><issue>5</issue><spage>266</spage><epage>271</epage><pages>266-271</pages><issn>0001-5652</issn><eissn>1423-0062</eissn><coden>HUHEAS</coden><abstract>DNA polymorphism at the ABO locus was investigated using denaturing gradient gel electrophoresis of polymerase-chain-reaction-amplified DNA products from 315 healthy individuals of the Chinese population of Hong Kong. Five different alleles were identified: ABO*A1, O2, A1, A2 and B1. The ABO*A2 is a new allele not previously reported in the literature. The allele frequencies found were 0.3698 for O1, 0.2508 for O2, 0.1952 for A1, 0.0159 for A2, and 0.1683 for B1. The Chinese population being investigated was in Hardy-Weinberg equilibrium. The genotyping method identifies many more alleles in the ABO locus and thus makes it a more useful genetic marker in linkage analysis, paternity testing and individualization in forensic work than when the locus is genotyped using conventional DNA-based methods or phenotyped using serological methods.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>7590758</pmid><doi>10.1159/000154311</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0001-5652
ispartof Human heredity, 1995-09, Vol.45 (5), p.266-271
issn 0001-5652
1423-0062
language eng
recordid cdi_proquest_miscellaneous_77619199
source JSTOR Archival Journals and Primary Sources Collection
subjects ABO Blood-Group System - genetics
Adult
Alleles
Base Sequence
Biological and medical sciences
China - ethnology
DNA - blood
DNA - genetics
DNA Primers
Europe - ethnology
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Hong Kong
Human
Humans
Molecular Sequence Data
Original Paper
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic
Population genetics, reproduction patterns
title DNA Polymorphism at the ABO Locus in the Chinese Population of Hong Kong
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T21%3A10%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=DNA%20Polymorphism%20at%20the%20ABO%20Locus%20in%20the%20Chinese%20Population%20of%20Hong%20Kong&rft.jtitle=Human%20heredity&rft.au=Yip,%20S.P.&rft.date=1995-09-01&rft.volume=45&rft.issue=5&rft.spage=266&rft.epage=271&rft.pages=266-271&rft.issn=0001-5652&rft.eissn=1423-0062&rft.coden=HUHEAS&rft_id=info:doi/10.1159/000154311&rft_dat=%3Cproquest_pubme%3E77619199%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c424t-c26f68220748dd297646ff48b3c749f12e7eae3d60994c6c96138ac5789a64b13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=77619199&rft_id=info:pmid/7590758&rfr_iscdi=true