Genomic 5-methyldeoxycytidine decreases with age

Significant losses of DNA 5-methyldeoxycytidine residues in old age could disrupt cellular gene expression and contribute to the physiological decline of the animal. Thus, the 5-methyldeoxycytidine content of DNAs, isolated from the tissues of two rodent species of various ages, were determined. Mus...

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Bibliographic Details
Published in:The Journal of biological chemistry 1987-07, Vol.262 (21), p.9948-9951
Main Authors: Wilson, V.L., Smith, R.A., Ma, S., Cutler, R.G.
Format: Article
Language:English
Subjects:
Ageing, cell death
Aging
Animals
Applied sciences
Biological and medical sciences
Brain Chemistry
Cell physiology
Deoxycytidine - analogs & derivatives
Deoxycytidine - analysis
DNA - analysis
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Humans
Intestinal Mucosa - analysis
Intestine, Small - analysis
Liver - analysis
Male
Methylation
Mice
Mice, Inbred C57BL
Molecular and cellular biology
Other techniques and industries
Peromyscus
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Summary:Significant losses of DNA 5-methyldeoxycytidine residues in old age could disrupt cellular gene expression and contribute to the physiological decline of the animal. Thus, the 5-methyldeoxycytidine content of DNAs, isolated from the tissues of two rodent species of various ages, were determined. Mus musculus lost DNA methylation sites at a rate of about 4.7×10(4) (approximately 0.012% of the newborn level)/month. Peromyscus leucopus lost DNA 5-methyldeoxycytidine residues at a rate of only 2.3×10(4) (approximately 0.006% of the newborn level)/month. Since P. leucopus generally live twice as long as M. musculus, the rate of loss of DNA 5-methyldeoxycytidine residues appears to be inversely related to life span. Similar losses in genomic 5-methyldeoxycytidine content were also observed to correlate with donor age in cultured normal human bronchial epithelial cells.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)61057-9