Linkage Disequilibrium Utilized to Establish a Refined Genetic Position of the Salla Disease Locus on 6q14-q15

Salla disease (SD), an inherited free sialic acid storage disorder, is caused by impaired transport of free sialic acid across the lysosomal membrane. Clinical characteristics of the disease include severe psychomotor retardation and some neurological abnormalities. We report here detailed linkage a...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1995-05, Vol.27 (2), p.286-292
Main Authors: Schleutker, Johanna, Laine, Antti-Pekka, Haataja, Leena, Renlund, Martin, Weissenbach, Jean, Aula, Pertti, Peltonen, Leena
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 6
DNA - analysis
Female
Finland
Haplotypes
Humans
Linkage Disequilibrium
Lod Score
Lysosomal Storage Diseases - genetics
Male
Medical sciences
Metabolic diseases
Miscellaneous
N-Acetylneuraminic Acid
Other metabolic disorders
Sialic Acids - genetics
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Summary:Salla disease (SD), an inherited free sialic acid storage disorder, is caused by impaired transport of free sialic acid across the lysosomal membrane. Clinical characteristics of the disease include severe psychomotor retardation and some neurological abnormalities. We report here detailed linkage analyses of 50 Finnish SD families that localize the SD disease gene to a refined chromosomal area on 6q14-q15. The highest lod score of 17.30 was obtained with a microsatellite marker of locus D6S280. When linkage disequilibrium was adopted in the linkage analyses, we could further assign the SD locus to the immediate vicinity of marker locus D6S406. Linkage disequilibrium facilitated further restriction of the critical chromosomal region to approximately 80 kb, well within the limits of positional cloning techniques.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1995.1044