Target-independent pattern specification in the olfactory epithelium

In mammals, odors are detected by ∼ 1000 different types of odorant receptors (ORs), each expressed by a fraction of neurons in the olfactory epithelium. Neurons expressing a given OR are confined to one of four spatial zones but are distributed randomly throughout that zone. In the olfactory bulb,...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1995-10, Vol.15 (4), p.779-789
Main Authors: Sullivan, Susan L., Bohm, Staffan, Ressler, Kerry J., Horowitz, Lisa F., Buck, Linda B.
Format: Article
Language:English
Subjects:
Animals
Cations
Cell Differentiation
Epithelium - embryology
Epithelium - metabolism
Gene Expression
GTP-Binding Proteins - genetics
Immunohistochemistry
In Situ Hybridization
Ion Channels - genetics
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mutation
Olfactory Bulb - abnormalities
Olfactory Bulb - embryology
Olfactory Bulb - physiology
Olfactory Mucosa - embryology
Olfactory Mucosa - metabolism
Receptors, Odorant - genetics
Signal Transduction
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Summary:In mammals, odors are detected by ∼ 1000 different types of odorant receptors (ORs), each expressed by a fraction of neurons in the olfactory epithelium. Neurons expressing a given OR are confined to one of four spatial zones but are distributed randomly throughout that zone. In the olfactory bulb, the axons of neurons expressing different ORs synapse at different sites, giving rise to a highly organized and stereotyped information map. An important issue is whether the epithelial and bulbar maps evolve independently or are linked, for example, by retrograde influences of the bulb on the epithelium. Here we examined the onset of expression and patterning of genes encoding ORs and sensory transduction molecules during mouse embryogenesis and in mice lacking olfactory bulbs. Our results argue for an independent development of epithelial and bulbar maps and an early functional development that may be pertinent to pattern development in the olfactory bulb.
ISSN:0896-6273
1097-4199
DOI:10.1016/0896-6273(95)90170-1