Chrysospermins, new peptaibol antibiotics from Apiocrea chrysosperma Ap101

Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma Ap101 by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed sp...

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Bibliographic Details
Published in:Journal of antibiotics 1995, Vol.48 (9), p.977-989
Main Authors: DORNBERGER, K, IHN, W, RITZAU, M, GRÄFE, U, SCHLEGEL, B, FLECK, W. F, METZGER, J. W
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acids - analysis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Ascomycota
Biological and medical sciences
Fermentation
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Molecular Sequence Data
Peptides - chemistry
Peptides - isolation & purification
Peptides - pharmacology
Pharmacology. Drug treatments
Spectrometry, Mass, Fast Atom Bombardment
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Summary:Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma Ap101 by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed spectroscopic analysis and chemical degradation experiments. The chrysospermins display antibacterial and antifungal activity, and induce pigment formation by the fungus Phoma destructiva.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.977