Decreased phospholipid polyunsaturated fatty acid content and superoxide dismutase activity in cardiac muscle of malignant hyperthermia-susceptible swine

Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in t...

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Bibliographic Details
Published in:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 1995-10, Vol.112 (2), p.283-286
Main Authors: Wahle, Klaus W.J., Morrice, Philip C., Arthur, John R., Duthie, Garry G.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - analysis
Cardiac muscle
Essential fatty acids
Fatty Acids, Unsaturated - analysis
Lipid peroxidation
Lipids - analysis
Malignant hyperthermia
Malignant Hyperthermia - metabolism
Myocardium - metabolism
Selenium - analysis
Superoxide dismutase
Superoxide Dismutase - analysis
Swine
Vitamin E - analysis
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Summary:Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90% vs 60%), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.
ISSN:1096-4959
1879-1107
DOI:10.1016/0305-0491(95)00072-0