T Cell Awareness of Paternal Alloantigens During Pregnancy

During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2K$^b$ was used to follow the fate of T cells rea...

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Published in:Science (American Association for the Advancement of Science) 1995-10, Vol.270 (5236), p.630-633
Main Authors: Tafuri, Anna, Alferink, Judith, Möller, Peter, Hämmerling, Günter J., Arnold, Bernd
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Autoimmunity
B lymphocytes
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cellular biology
Fathers
Female
Fetus
Fetus - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetic aspects
Genetics
Graft Rejection
H-2 Antigens - immunology
Histocompatibility antigens
HLA antigens
HLA histocompatibility antigens
Immune Tolerance
Immunobiology
Immunological tolerance
Isoantigens
Male
Males
Mice
Mice, Inbred C57BL
Mice, SCID
Mice, Transgenic
Neoplasm Transplantation
Phenotype
Placenta - immunology
Pregnancy
Pregnancy, Animal - immunology
Receptors, Antigen, T-Cell - immunology
Rodents
Splenocytes
T cell antigen receptors
T cells
T lymphocytes
T-Lymphocytes - immunology
Transgenic animals
Tumors
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cited_by cdi_FETCH-LOGICAL-c746t-6efef1f8b76e06bc06d45e2ebffc8992fe4b1de032d2e27acc10b8a0f99860a43
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container_issue 5236
container_start_page 630
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creator Tafuri, Anna
Alferink, Judith
Möller, Peter
Hämmerling, Günter J.
Arnold, Bernd
description During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2K$^b$ was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a K$^b$-positive conceptus had reduced numbers of K$^b$-reactive T cells and accepted K$^b$-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens.
doi_str_mv 10.1126/science.270.5236.630
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A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2K$^b$ was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a K$^b$-positive conceptus had reduced numbers of K$^b$-reactive T cells and accepted K$^b$-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. 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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1995-10, Vol.270 (5236), p.630-633
issn 0036-8075
1095-9203
language eng
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source American Association for the Advancement of Science; Social Science Premium Collection; Education Collection
subjects AIDS/HIV
Animals
Autoimmunity
B lymphocytes
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cellular biology
Fathers
Female
Fetus
Fetus - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetic aspects
Genetics
Graft Rejection
H-2 Antigens - immunology
Histocompatibility antigens
HLA antigens
HLA histocompatibility antigens
Immune Tolerance
Immunobiology
Immunological tolerance
Isoantigens
Male
Males
Mice
Mice, Inbred C57BL
Mice, SCID
Mice, Transgenic
Neoplasm Transplantation
Phenotype
Placenta - immunology
Pregnancy
Pregnancy, Animal - immunology
Receptors, Antigen, T-Cell - immunology
Rodents
Splenocytes
T cell antigen receptors
T cells
T lymphocytes
T-Lymphocytes - immunology
Transgenic animals
Tumors
title T Cell Awareness of Paternal Alloantigens During Pregnancy
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