Allele-Dependent Recombination Frequency: Homology Requirement in Meiotic Recombination at the Hot Spot in the Mouse Major Histocompatibility Complex

Meiotic recombination break joints in the mouse major histocompatibility complex (MHC) are clustered within short segments known as hot spots. We systematically investigated the requirement for sequence homology between two chromosomes for recombination activity at the hot spot next to the Lmp2 gene...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1995-05, Vol.27 (2), p.298-305
Main Authors: Yoshino, Masayasu, Sagai, Tomoko, Lindahl, Kirsten Fischer, Toyoda, Yutaka, Moriwaki, Kazuo, Shiroishi, Toshihiko
Format: Article
Language:English
Subjects:
Alleles
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
Cysteine Endopeptidases
DNA - chemistry
Female
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Haplotypes
Humans
Major Histocompatibility Complex - genetics
Male
Meiosis
Mice
Mice, Inbred Strains
Molecular Sequence Data
Polymorphism, Genetic
Proteins - genetics
Recombination, Genetic
Sequence Homology, Nucleic Acid
Vertebrata
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Summary:Meiotic recombination break joints in the mouse major histocompatibility complex (MHC) are clustered within short segments known as hot spots. We systematically investigated the requirement for sequence homology between two chromosomes for recombination activity at the hot spot next to the Lmp2 gene. The results indicated that a high rate of recombination required a high degree of similarity of overall genome structure at the hot spot. In particular, the same copy number of repetitive sequences within the hot spot was essential for a high frequency of recombination, suggesting that recombination in mouse meiosis is more sensitive to heterozygous deletion or insertion of DNA than to mismatches of single-base substitutions.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1995.1046