Positive selection of T cells

In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive...

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Bibliographic Details
Published in:Current opinion in immunology 1995-04, Vol.7 (2), p.188-195
Main Authors: Fowlkes, BJ, Schweighoffer, Edina
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cell Differentiation - genetics
Receptors, Antigen, T-Cell - genetics
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Summary:In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive selection, and in analyzing the contribution of MHC and co-receptors to CD4/CD8 lineage commitment. The most revealing studies have been those addressing the role of peptides in thymic selection.
ISSN:0952-7915
1879-0372
DOI:10.1016/0952-7915(95)80003-4