Transdifferentiation as a basis for amphibian limb regeneration

Limb regeneration is a phenomenon occurring only in some urodeles. The process seems to be initiated by the dedifferentiation of the terminally differentiated cells. These cells differentiate, subsequently, to the tissues that comprise the limb, thus reconstructing the pattern of the missing limb pa...

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Bibliographic Details
Published in:Seminars in cell biology 1995-06, Vol.6 (3), p.127-135
Main Authors: Tsonis, Panagiotis A., Washabaugh, Charles H., Del Rio-Tsonis, Katia
Format: Article
Language:English
Subjects:
Amphibia
Amphibians - physiology
Animals
cell culture
Cell Differentiation
cyclins
dedifferentiation
Extremities - physiology
Freshwater
metaplasia
myf-5
Regeneration
Urodela
urodeles
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Summary:Limb regeneration is a phenomenon occurring only in some urodeles. The process seems to be initiated by the dedifferentiation of the terminally differentiated cells. These cells differentiate, subsequently, to the tissues that comprise the limb, thus reconstructing the pattern of the missing limb part. In this paper we review and present evidence that certain cell types of the limb have the capacity to differentiate to different cell types than their original one by cellular metaplasia. This switch is called transdifferentiation. The focus of this review is the process of dedifferentiation which is the necessary prerequisite for differentiation, and the possible mechanisms involved.
ISSN:1043-4682
1522-967X
DOI:10.1006/scel.1995.0018