Effect of melatonin on active transport of serotonin into blood platelets

Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to in...

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Bibliographic Details
Published in:Psychiatry research 1995-07, Vol.57 (2), p.193-196
Main Authors: Valevski, Avi, Modal, Ilan, Jerushalmy, Zohara, Kikinzon, Leonid, Weizman, Abraham
Format: Article
Language:English
Subjects:
5-Hydroxytryptamine
Adult
Blood Platelets
Circadian Rhythm
Humans
Male
Melatonin - blood
Melatonin - pharmacokinetics
Pharmacokinetics
Pineal Gland - metabolism
Serotonin - blood
Serotonin - metabolism
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Summary:Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10 −6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10 −12M to 2 × 10 −9M) and at high nonphysiological concentrations (2 × 10 −8M to 2 × 10 −3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10 −5M with IC 50 value of 1.1 × 10 −3M) and had no effect at physiological concentrations.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(95)02642-A