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Effect of melatonin on active transport of serotonin into blood platelets
Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to in...
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| Published in: | Psychiatry research 1995-07, Vol.57 (2), p.193-196 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c357t-4007eabdc8bdc803d3c099b6fab44f491873d6c511fc8dcfdef9a63f816072813 |
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| cites | cdi_FETCH-LOGICAL-c357t-4007eabdc8bdc803d3c099b6fab44f491873d6c511fc8dcfdef9a63f816072813 |
| container_end_page | 196 |
| container_issue | 2 |
| container_start_page | 193 |
| container_title | Psychiatry research |
| container_volume | 57 |
| creator | Valevski, Avi Modal, Ilan Jerushalmy, Zohara Kikinzon, Leonid Weizman, Abraham |
| description | Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10
−6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10
−12M to 2 × 10
−9M) and at high nonphysiological concentrations (2 × 10
−8M to 2 × 10
−3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10
−5M with IC
50 value of 1.1 × 10
−3M) and had no effect at physiological concentrations. |
| doi_str_mv | 10.1016/0165-1781(95)02642-A |
| format | article |
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−6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10
−12M to 2 × 10
−9M) and at high nonphysiological concentrations (2 × 10
−8M to 2 × 10
−3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10
−5M with IC
50 value of 1.1 × 10
−3M) and had no effect at physiological concentrations.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(95)02642-A</identifier><identifier>PMID: 7480385</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>5-Hydroxytryptamine ; Adult ; Blood Platelets ; Circadian Rhythm ; Humans ; Male ; Melatonin - blood ; Melatonin - pharmacokinetics ; Pharmacokinetics ; Pineal Gland - metabolism ; Serotonin - blood ; Serotonin - metabolism</subject><ispartof>Psychiatry research, 1995-07, Vol.57 (2), p.193-196</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-4007eabdc8bdc803d3c099b6fab44f491873d6c511fc8dcfdef9a63f816072813</citedby><cites>FETCH-LOGICAL-c357t-4007eabdc8bdc803d3c099b6fab44f491873d6c511fc8dcfdef9a63f816072813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7480385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valevski, Avi</creatorcontrib><creatorcontrib>Modal, Ilan</creatorcontrib><creatorcontrib>Jerushalmy, Zohara</creatorcontrib><creatorcontrib>Kikinzon, Leonid</creatorcontrib><creatorcontrib>Weizman, Abraham</creatorcontrib><title>Effect of melatonin on active transport of serotonin into blood platelets</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10
−6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10
−12M to 2 × 10
−9M) and at high nonphysiological concentrations (2 × 10
−8M to 2 × 10
−3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10
−5M with IC
50 value of 1.1 × 10
−3M) and had no effect at physiological concentrations.</description><subject>5-Hydroxytryptamine</subject><subject>Adult</subject><subject>Blood Platelets</subject><subject>Circadian Rhythm</subject><subject>Humans</subject><subject>Male</subject><subject>Melatonin - blood</subject><subject>Melatonin - pharmacokinetics</subject><subject>Pharmacokinetics</subject><subject>Pineal Gland - metabolism</subject><subject>Serotonin - blood</subject><subject>Serotonin - metabolism</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLwzAUx4Moc06_gUJPoodq0rRNcxHGmDoYeNFzSJMXiLRNTbqB3950HTt6eOTwfv-X934I3RL8RDApn2MVKWEVeeDFI87KPEuXZ2hOKpaljGT0HM1PyCW6CuEbY5wRzmdoxvIK06qYo83aGFBD4kzSQiMH19kucV0i1WD3kAxedqF3_gAE8G4CbDe4pG6c00kfQ9DAEK7RhZFNgJvju0Bfr-vP1Xu6_XjbrJbbVNGCDWmOMQNZa1WNhammCnNel0bWeW5yHtenulQFIUZVWhkNhsuSmoqUmGUVoQt0P83tvfvZQRhEa4OCppEduF0QjJWUx0MjmE-g8i4ED0b03rbS_wqCxWhQjHrEqEfwQhwMimWM3R3n7-oW9Cl0VBb7L1Mf4pF7C14EZaFToK2PJoV29v8P_gAFIYCJ</recordid><startdate>19950728</startdate><enddate>19950728</enddate><creator>Valevski, Avi</creator><creator>Modal, Ilan</creator><creator>Jerushalmy, Zohara</creator><creator>Kikinzon, Leonid</creator><creator>Weizman, Abraham</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950728</creationdate><title>Effect of melatonin on active transport of serotonin into blood platelets</title><author>Valevski, Avi ; Modal, Ilan ; Jerushalmy, Zohara ; Kikinzon, Leonid ; Weizman, Abraham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4007eabdc8bdc803d3c099b6fab44f491873d6c511fc8dcfdef9a63f816072813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>5-Hydroxytryptamine</topic><topic>Adult</topic><topic>Blood Platelets</topic><topic>Circadian Rhythm</topic><topic>Humans</topic><topic>Male</topic><topic>Melatonin - blood</topic><topic>Melatonin - pharmacokinetics</topic><topic>Pharmacokinetics</topic><topic>Pineal Gland - metabolism</topic><topic>Serotonin - blood</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valevski, Avi</creatorcontrib><creatorcontrib>Modal, Ilan</creatorcontrib><creatorcontrib>Jerushalmy, Zohara</creatorcontrib><creatorcontrib>Kikinzon, Leonid</creatorcontrib><creatorcontrib>Weizman, Abraham</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valevski, Avi</au><au>Modal, Ilan</au><au>Jerushalmy, Zohara</au><au>Kikinzon, Leonid</au><au>Weizman, Abraham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of melatonin on active transport of serotonin into blood platelets</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1995-07-28</date><risdate>1995</risdate><volume>57</volume><issue>2</issue><spage>193</spage><epage>196</epage><pages>193-196</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><abstract>Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10
−6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10
−12M to 2 × 10
−9M) and at high nonphysiological concentrations (2 × 10
−8M to 2 × 10
−3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10
−5M with IC
50 value of 1.1 × 10
−3M) and had no effect at physiological concentrations.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>7480385</pmid><doi>10.1016/0165-1781(95)02642-A</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-1781 |
| ispartof | Psychiatry research, 1995-07, Vol.57 (2), p.193-196 |
| issn | 0165-1781 1872-7123 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77639002 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | 5-Hydroxytryptamine Adult Blood Platelets Circadian Rhythm Humans Male Melatonin - blood Melatonin - pharmacokinetics Pharmacokinetics Pineal Gland - metabolism Serotonin - blood Serotonin - metabolism |
| title | Effect of melatonin on active transport of serotonin into blood platelets |
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