Acquired cutis laxa associated with chronic urticaria

A 31-year-old man had cutis laxa after an urticarial eruption. He had no systemic manifestations. In urticarial lesions, elastolysis occurred only within the inflammatory infiltrate of neutrophils around the vessels and between the collagen bundles. In lax skin, elastolysis occurred throughout the e...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1995-11, Vol.33 (5), p.896-899
Main Authors: Chun, Soo Il, Yoon, Juho
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
Biological and medical sciences
Biopsy
Chronic Disease
Cutis Laxa - etiology
Elastic Tissue - ultrastructure
Elastin - ultrastructure
Epidermis - pathology
Fibroblasts - ultrastructure
Humans
Immunopathology
Male
Medical sciences
Microscopy, Electron
Neck
Skin - pathology
Skin allergic diseases. Stinging insect allergies
Thorax
Urticaria - complications
Urticaria - pathology
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Description
Summary:A 31-year-old man had cutis laxa after an urticarial eruption. He had no systemic manifestations. In urticarial lesions, elastolysis occurred only within the inflammatory infiltrate of neutrophils around the vessels and between the collagen bundles. In lax skin, elastolysis occurred throughout the entire dermis. Electron microscopic study showed a markedly decreased number of elastic fibers, with elastolysis most predominant near the inflammatory cells. These findings suggest that the neutrophil plays a significant role in the destruction of elastic fibers and subsequent development of cutis laxa.
ISSN:0190-9622
1097-6787
DOI:10.1016/0190-9622(95)90431-X