Neuronal death after perinatal asphyxia

During perinatal asphyxia several mechanisms aim to limit cerebral damage. However, when the degree of asphyxia passes beyond a certain threshold, brain damage is inevitable. This review focuses on the various factors determining the final cerebral outcome. Metabolic and biochemical events, such as...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 1995-08, Vol.61 (2), p.123-127
Main Authors: de Haan, Harmen H., Hasaart, Tom H.M.
Format: Article
Language:English
Subjects:
Asphyxia
Asphyxia Neonatorum - complications
Asphyxia Neonatorum - metabolism
Asphyxia Neonatorum - pathology
Biological and medical sciences
Brain Diseases - etiology
Brain Diseases - prevention & control
Calcium - metabolism
Cell Death
Cerebral damage
Delivery. Postpartum. Lactation
Disorders
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Medical sciences
Neuronal death
Neurons - pathology
Oxygen derived free radicals
Reactive Oxygen Species - metabolism
Review
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Summary:During perinatal asphyxia several mechanisms aim to limit cerebral damage. However, when the degree of asphyxia passes beyond a certain threshold, brain damage is inevitable. This review focuses on the various factors determining the final cerebral outcome. Metabolic and biochemical events, such as the intracellular level of calcium, the formation of oxygen derived free radicals, the release of excitotoxic neurotransmitters and the interrelationship of these parameters are discussed. Furthermore, steps possibly useful to pharmacologic intervention aiming to reduce cerebral damage are presented.
ISSN:0301-2115
1872-7654
DOI:10.1016/0301-2115(95)02127-S