Maximum variance of late component event related potentials (190–240 ms) in unmedicated schizophrenic patients

The averaging of individual late component event related potential (ERP) responses, particularly P300, has revealed significant differences between schizophrenic patients and normal subjects. However, the averaging process removes the variability of the individual epochs that constitute that average...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research 1995-04, Vol.56 (3), p.229-236
Main Authors: Anderson, John, Gordon, Evian, Barry, Robert J., Rennie, Christopher, Beumont, Pierre J.V., Meares, Russell
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adult
Analysis of Variance
Electrophysiology
Evoked Potentials, Auditory - physiology
Humans
Information processing
Neuroleptic effects
Psychiatric Status Rating Scales
Schizophrenia - physiopathology
Schizophrenic Psychology
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The averaging of individual late component event related potential (ERP) responses, particularly P300, has revealed significant differences between schizophrenic patients and normal subjects. However, the averaging process removes the variability of the individual epochs that constitute that average. The response-variance-curve (RVC) method quantifies the variability of the individual epochs and allows examinations of windows of maximum variance. In this study, we examine the complementary nature of the RVC method to the traditional averaging approach. The averaged N200 and P300 ERP components differed significantly between the schizophrenic and normal groups, but not between the unmedicated and medicated schizophrenic patients. The RVC measure, on the other hand, revealed systematic differences in variability, maximal between 190 and 240 ms, between the unmedicated and medicated schizophrenic patients. The RVC measure therefore provides a focused time frame in which to examine dysfunctions in information processing and macroscopic scale changes in brain function due to medication.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(95)02556-C