Immunomodulating effects of the new anti-rheumatic drug tenidap on collagen-induced arthritis

We investigated the in vivo action of the newly developed anti-rheumatic agent tenidap, CP-66,248 (Pfizer Inc., New York), on arthritis in collagen-induced arthritic mice. The inhibitory effect of tenidap on the development of arthritis was statistically more significant than piroxicam. The serum an...

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Bibliographic Details
Published in:International journal of immunopharmacology 1995-03, Vol.17 (3), p.213-219
Main Authors: Matsushita, Isao, Matsuno, Hiroaki, Kadowaki, Ken M., Okada, Chisako, Tsuji, Haruo
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antibody Formation
Arthritis, Experimental - drug therapy
Arthritis, Experimental - immunology
Arthritis, Experimental - physiopathology
Arthrography
Autoantibodies - blood
Autoantibodies - drug effects
Autoantibodies - immunology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Collagen - immunology
collagen-induced arthritis
Extremities - diagnostic imaging
Female
immunomodulating effect
Indoles - chemistry
Indoles - pharmacology
Medical sciences
Mice
Mice, Inbred DBA
Pharmacology. Drug treatments
Piroxicam - pharmacology
tenidap
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Summary:We investigated the in vivo action of the newly developed anti-rheumatic agent tenidap, CP-66,248 (Pfizer Inc., New York), on arthritis in collagen-induced arthritic mice. The inhibitory effect of tenidap on the development of arthritis was statistically more significant than piroxicam. The serum anti-type II collagen antibody titer was markedly inhibited in the mice treated by tenidap. These results suggest that, unlike NSAIDs, tenidap inhibits the progress of collagen-induced arthritis through its immunomodulating effect.
ISSN:0192-0561
1879-3495
DOI:10.1016/0192-0561(95)00004-L