Successful treatment of generalized lichen planus with recombinant interferon alfa-2b

Three patients with generalized lichen planus were treated with interferon alfa-2b. The therapy was tolerated well by all patients with only minor side effects. A response was observed within 2 to 3 weeks. Itching and erythema decreased first, followed by gradual flattening and disappearance of papu...

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Published in:Journal of the American Academy of Dermatology 1995-11, Vol.33 (5), p.880-883
Main Authors: Hildebrand, Axel, Kolde, Gerhard, Luger, Thomas A, Schwarz, Thomas
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Agents - therapeutic use
Antiviral Agents - therapeutic use
Biological and medical sciences
Female
Humans
Interferon alpha-2
Interferon-alpha - therapeutic use
Lichen Planus - therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Recombinant Proteins
Skin, nail, hair, dermoskeleton
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cited_by cdi_FETCH-LOGICAL-c386t-bf8be276023b16b4e281e2332ac2d3f261a40d48d3d6a22358c911ce875bb13a3
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container_title Journal of the American Academy of Dermatology
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creator Hildebrand, Axel
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description Three patients with generalized lichen planus were treated with interferon alfa-2b. The therapy was tolerated well by all patients with only minor side effects. A response was observed within 2 to 3 weeks. Itching and erythema decreased first, followed by gradual flattening and disappearance of papules and plaques after 8 to 10 weeks of treatment. After 12 weeks, therapy was discontinued after stepwise dosage reduction. In two patients, minor lesions recurred during dosage reduction. Both flares were controlled by readministration of interferon.
doi_str_mv 10.1016/0190-9622(95)90427-1
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ispartof Journal of the American Academy of Dermatology, 1995-11, Vol.33 (5), p.880-883
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subjects Adult
Antineoplastic Agents - therapeutic use
Antiviral Agents - therapeutic use
Biological and medical sciences
Female
Humans
Interferon alpha-2
Interferon-alpha - therapeutic use
Lichen Planus - therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Recombinant Proteins
Skin, nail, hair, dermoskeleton
title Successful treatment of generalized lichen planus with recombinant interferon alfa-2b
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