Effects of daytime administration of zolpidem versus triazolam on memory

To determine whether zolpidem (an imidazopyridine hypnotic) produces amnestic effects which are similar to those produced by triazolam (a benzodiazepine hypnotic), 70 subjects were administered either triazolam (0.125, 0.25, or 0.5 mg), zolpidem (5, 10, or 15 mg) or placebo, then tested on Simulated...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1995-06, Vol.48 (2), p.115-122
Main Authors: WESENSTEN, N. J, BALKIN, T. J, BELENKY, G. L
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Biological and medical sciences
Double-Blind Method
Drug toxicity and drugs side effects treatment
Humans
Hypnotics and Sedatives - pharmacology
Medical sciences
Memory - drug effects
Mental Recall - drug effects
Pharmacology. Drug treatments
Polysomnography - drug effects
Pyridines - pharmacology
Sleep - drug effects
Time Factors
Toxicity: nervous system and muscle
Triazolam - pharmacology
Zolpidem
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Summary:To determine whether zolpidem (an imidazopyridine hypnotic) produces amnestic effects which are similar to those produced by triazolam (a benzodiazepine hypnotic), 70 subjects were administered either triazolam (0.125, 0.25, or 0.5 mg), zolpidem (5, 10, or 15 mg) or placebo, then tested on Simulated Escape, Restricted Reminding, and Paired-Associates memory tests at 1.5 hours post-dosing (i.e., near the time of estimated peak blood concentration for both drugs) and again at 6 hours post-dosing. Triazolam 0.5 mg produced the greatest memory impairment at both test times, and also produced the greatest degree of sedation during intervening daytime naps in a non-sleep-conducive environment. Other doses of triazolam and zolpidem produced less memory impairment, but also failed to significantly enhance sleep. The results are consistent with the view that the amnestic and hypnotic effects of these sleep-inducing medications are functionally coupled.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00192735