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Dopamine Regulation of Transcription Factor-Target Interactions in Rat Striatum

Transcriptional regulation is an important mechanism by which neurons adapt to environmental stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum...

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Published in:Chemical senses 1995-04, Vol.20 (2), p.257-260
Main Authors: Hyman, Steven E., Cole, Rebecca L., Konradi, Christine, Kosofsky, Barry E.
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container_title Chemical senses
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creator Hyman, Steven E.
Cole, Rebecca L.
Konradi, Christine
Kosofsky, Barry E.
description Transcriptional regulation is an important mechanism by which neurons adapt to environmental stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. Here we show that phosphorylation of transcription factor CREB is a critical early event coupling dopamine stimulation to gene regulation. CREB interacts with functional regulatory elements in both the c-fos and prodynorphin genes, and is phosphorylated in response to dopamine in a D1 dopamine receptor-dependent manner. In addition, we show by intra-striatal injection of antisense oligonucleotides directed against CREB mRNA, that CREB protein is required for c-fos induction by amphetamine.
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ispartof Chemical senses, 1995-04, Vol.20 (2), p.257-260
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source Oxford University Press Archive
subjects Animals
Biochemistry and metabolism
Biological and medical sciences
Central nervous system
Corpus Striatum - physiology
Dopamine - physiology
Dopamine Agonists - pharmacology
Dopamine Antagonists - pharmacology
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
Rats
Transcription Factors - physiology
Vertebrates: nervous system and sense organs
title Dopamine Regulation of Transcription Factor-Target Interactions in Rat Striatum
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