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Dopamine Regulation of Transcription Factor-Target Interactions in Rat Striatum
Transcriptional regulation is an important mechanism by which neurons adapt to environmental stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum...
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Published in: | Chemical senses 1995-04, Vol.20 (2), p.257-260 |
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container_issue | 2 |
container_start_page | 257 |
container_title | Chemical senses |
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creator | Hyman, Steven E. Cole, Rebecca L. Konradi, Christine Kosofsky, Barry E. |
description | Transcriptional regulation is an important mechanism by which neurons adapt to environmental stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. Here we show that phosphorylation of transcription factor CREB is a critical early event coupling dopamine stimulation to gene regulation. CREB interacts with functional regulatory elements in both the c-fos and prodynorphin genes, and is phosphorylated in response to dopamine in a D1 dopamine receptor-dependent manner. In addition, we show by intra-striatal injection of antisense oligonucleotides directed against CREB mRNA, that CREB protein is required for c-fos induction by amphetamine. |
doi_str_mv | 10.1093/chemse/20.2.257 |
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In addition, we show by intra-striatal injection of antisense oligonucleotides directed against CREB mRNA, that CREB protein is required for c-fos induction by amphetamine.</description><identifier>ISSN: 0379-864X</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/20.2.257</identifier><identifier>PMID: 7583020</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Corpus Striatum - physiology ; Dopamine - physiology ; Dopamine Agonists - pharmacology ; Dopamine Antagonists - pharmacology ; Fundamental and applied biological sciences. 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The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. Here we show that phosphorylation of transcription factor CREB is a critical early event coupling dopamine stimulation to gene regulation. CREB interacts with functional regulatory elements in both the c-fos and prodynorphin genes, and is phosphorylated in response to dopamine in a D1 dopamine receptor-dependent manner. 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subjects | Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Corpus Striatum - physiology Dopamine - physiology Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Rats Transcription Factors - physiology Vertebrates: nervous system and sense organs |
title | Dopamine Regulation of Transcription Factor-Target Interactions in Rat Striatum |
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