T cytotoxic and helper cells are markedly increased, and t suppressor and inducer cells are markedly decreased, in rheumatoid synovial fluids

Synovial fluid lymphocytes and paired peripheral blood lymphocytes from 28 patients with rheumatoid arthritis were analyzed by 2‐dimensional flow cytometry. We found that the composition of the lymphocyte population is different in synovial fluid compared with that in peripheral blood, in that there...

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Bibliographic Details
Published in:Arthritis and rheumatism 1987-07, Vol.30 (7), p.737-743
Main Authors: Goto, Makoto, Miyamoto, Terumasa, Nishioka, Kusuki, Uchida, Shoji
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - immunology
Biological and medical sciences
Cell Separation
Diseases of the osteoarticular system
Female
Flow Cytometry
Fluorescent Antibody Technique
Humans
Inflammatory joint diseases
Lymphocyte Activation
Male
Medical sciences
Middle Aged
Synovial Fluid - immunology
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:Synovial fluid lymphocytes and paired peripheral blood lymphocytes from 28 patients with rheumatoid arthritis were analyzed by 2‐dimensional flow cytometry. We found that the composition of the lymphocyte population is different in synovial fluid compared with that in peripheral blood, in that there were increased proportions of Ia+ Leu‐2a+/Leu‐15– (T cytotoxic) cells and Leu‐3a+/Leu‐8– (T helper) cells, together with marked decreases in Leu‐2a+/Leu‐15+ (T suppressor) cells and Leu‐3a+/Leu‐8+ (T inducer) cells. These findings suggest that the unique composition of synovial fluid lymphocytes might be the result of T cell activation by some mechanism that is not known.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780300703