Adrenomedullary chromaffin cells as a model to study the neurobiology of ascorbic acid: from monooxygenation to neuromodulation

In the past ten years, the authors have investigated both the intra- and extracellular functions of ascorbic acid using adrenomedullary chromaffin cells, an excellent model for the study of presynaptic events. They will review in this report some of their studies and more recent findings regarding t...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1987, Vol.498 (1), p.28-53
Main Authors: Diliberto, E.J. Jr, Menniti, F.S, Knoth, J, Daniels, A.J, Kizer, J.S, Viveros, O.H
Format: Article
Language:English
Subjects:
ACIDE ASCORBIQUE
ACIDO ASCORBICO
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
Adrenal Medulla - metabolism
Animals
ASCORBIC ACID
Ascorbic Acid - physiology
Biological Transport
Cells, Cultured
CHEMISTRY
CHIMIE
Chromaffin System - metabolism
Dopamine beta-Hydroxylase - metabolism
ENZYMIC ACTIVITY
FISIOLOGIA HUMANA
HORMONAS
HORMONE
HORMONES
HUMAN PHYSIOLOGY
Hypoglycemia - metabolism
Mixed Function Oxygenases
Multienzyme Complexes
NERVOUS SYSTEM
Neurotransmitter Agents - biosynthesis
NUTRIENT TRANSPORT
Oxygenases - metabolism
PHYSIOLOGIE HUMAINE
QUIMICA
SECRECION
SECRETION
SISTEMA NERVIOSO
Subcellular Fractions - metabolism
SYSTEME NERVEUX
TRANSPORT DES SUBSTANCES NUTRITIVES
TRANSPORTE DE NUTRIENTES
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Summary:In the past ten years, the authors have investigated both the intra- and extracellular functions of ascorbic acid using adrenomedullary chromaffin cells, an excellent model for the study of presynaptic events. They will review in this report some of their studies and more recent findings regarding the roles of ascorbic acid in neurotransmitter synthesis and the mechanism(s) of its secretion from adrenomedullary chromaffin cells.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1987.tb23749.x