CHLOROPOLYSPORINS A, B AND C, NOVEL GLYCOPEPTIDE ANTIBIOTICS FROM FAENIA INTERJECTA SP. NOV: IV. PARTIALLY DEGLYCOSYLATED DERIVATIVES

Chloropolysporins A, B and C, new members of the glycopeptide antibiotic family, were enzymatically and chemically converted to their partially deglycosylated derivatives. The α- and β-avoparcins were also deglycosylated by the same method. The conversions were achieved by treatments with rhamnosida...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1987/07/25, Vol.40(7), pp.941-945
Main Authors: TAKATSU, TOSHIO, TAKAHASHI, SHUJI, TAKAMATSU, YASUYUKI, SHIOIRI, TETSUYA, IWADO, SEIGO, HANEISHI, TATSUO
Format: Article
Language:English
Subjects:
alpha-Mannosidase
Anti-Bacterial Agents - analysis
beta-Glucosidase - metabolism
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
chloropolysporin A
chloropolysporin B
chloropolysporin C
deglycosylation
Faenia interjecta
General pharmacology
Glycopeptides - analysis
Glycopeptides - metabolism
Glycoside Hydrolases - metabolism
Glycosylation
Mannosidases - metabolism
Medical sciences
Micromonosporaceae - analysis
Multienzyme Complexes - metabolism
peptide antibiotics
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chloropolysporins A, B and C, new members of the glycopeptide antibiotic family, were enzymatically and chemically converted to their partially deglycosylated derivatives. The α- and β-avoparcins were also deglycosylated by the same method. The conversions were achieved by treatments with rhamnosidase (Naringinase) and α-mannosidase, and by mild acid hydrolysis.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.941