SPECT abnormalities in generalized dystonia

A patient with severe, generalized dystonia and 6 age range-matched controls were studied with the regional cerebral blood flow tracer technetium-99m hexamethylpropyleneamine oxime by single-photon emission computed tomography to test the hypothesis that cerebellar function is abnormal in dystonia....

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Bibliographic Details
Published in:Pediatric neurology 1995-07, Vol.13 (1), p.5-10
Main Authors: LeDoux, Mark S., Lane Rutledge, S., Mountz, James M., Darji, Jaykrishna T.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - blood supply
Brain Mapping
Cerebellar Nuclei - blood supply
Child
Contrast Media
Dominance, Cerebral - physiology
Dystonia - congenital
Dystonia - diagnostic imaging
Dystonia - physiopathology
Female
Follow-Up Studies
Humans
Medical sciences
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurologic Examination
Neurology
Organotechnetium Compounds
Oximes
Regional Blood Flow - physiology
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:A patient with severe, generalized dystonia and 6 age range-matched controls were studied with the regional cerebral blood flow tracer technetium-99m hexamethylpropyleneamine oxime by single-photon emission computed tomography to test the hypothesis that cerebellar function is abnormal in dystonia. Analysis was performed by drawing regions of interest around the caudate head nuclei, hemithalami, deep cerebellar nuclei, and cerebellar hemicortices. The counts in each region of interest were normalized to whole brain cerebral blood flow in an identical manner for each subject. The dystonic patient had a difference in regional cerebral blood flow between the right and left deep cerebellar nuclei, increased regional cerebral blood flow in subcortical motor structures, and an abnormal relationship between right cerebellar cortical and right deep cerebellar nuclear regional cerebral blood flow. The findings in this patient provide evidence that the cerebellum may play a role in the pathophysiology of motor signs in some patients with dystonia.
ISSN:0887-8994
1873-5150
DOI:10.1016/0887-8994(95)00109-S