Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk

The association between glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk has been controversial in the published literature. To examine this controversy, 12 case-control studies of GSTM1 status and lung cancer risk were identified in the published English literature. These studie...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1995-09, Vol.4 (6), p.589-594
Main Authors: McWilliams, J E, Sanderson, B J, Harris, E L, Richert-Boe, K E, Henner, W D
Format: Article
Language:English
Subjects:
Bias
Case-Control Studies
Confidence Intervals
Gene Expression
Glutathione Transferase - deficiency
Glutathione Transferase - genetics
Humans
Incidence
Lung Neoplasms - enzymology
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Odds Ratio
Polymorphism, Genetic
Risk Factors
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Summary:The association between glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk has been controversial in the published literature. To examine this controversy, 12 case-control studies of GSTM1 status and lung cancer risk were identified in the published English literature. These studies included a total of 1593 cases and 2135 controls. We conclude that GSTM1 deficiency is a moderate risk factor for lung cancer development with an odds ratio of 1.41 (95% confidence interval = 1.23-1.61; P < 0.0001) by using Mantel-Haenszel methods for stratified analysis. This increased risk is evident for all the major histological subtypes of lung cancer. Although the increased risk is small, GSTM1 deficiency accounts for approximately 17% of lung cancer cases because of the high prevalence of GSTM1 deficiency.
ISSN:1055-9965
1538-7755