PYRROXAMYCIN, A NEW ANTIBIOTIC TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

A strain of streptomycete was found to produce a new antibiotic pyrroxamycin. This compound was isolated from the culture broth of Streptomyces sp. S46506. The chemical structure was determined to be 4, 5-dichloro-2-(6', 8'-dichloro-4'H-1', 3'-benzodioxin-4'-yl)-3-nitro...

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Bibliographic Details
Published in:Journal of antibiotics 1987/07/25, Vol.40(7), pp.961-969
Main Authors: YANO, KENICHI, OONO, JUNJI, MOGI, KINICHI, ASAOKA, TAKEMITSU, NAKASHIMA, TOSHIAKI
Format: Article
Language:English
Subjects:
4,5-dichloro-2-(6',8'-dichloro-4'H-1',3'-benzodioxin-4'-yl)-3-nit r opyrrole
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - metabolism
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry, Physical
Fermentation
Fundamental and applied biological sciences. Psychology
gram-positive bacteria
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Production of active biomolecules
Pyrroles - isolation & purification
Pyrroles - metabolism
pyrroxamycin
Spectrophotometry, Infrared
Streptomyces
Streptomyces - analysis
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Summary:A strain of streptomycete was found to produce a new antibiotic pyrroxamycin. This compound was isolated from the culture broth of Streptomyces sp. S46506. The chemical structure was determined to be 4, 5-dichloro-2-(6', 8'-dichloro-4'H-1', 3'-benzodioxin-4'-yl)-3-nitropyrrole by its chemical character and 1H and 13C NMR spectral analysis. Pyrroxamycin was active against Gram-positive bacteria and dermatophytes.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.961