Succinate dehydrogenase and mitochondria in the hair cells in the organ of corti of mature and old shaker—1 mice

The activity of succinate dehydrogenase in the sensory hair cells in the organ of Corti of mature and old shaker-1 mice described as the animals grew older, the outer hair cells being the most effected. The decrease inactivity of this enzyme was closely linked with the degeneration of the mitochondr...

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Bibliographic Details
Published in:Journal of laryngology and otology 1987-07, Vol.101 (7), p.643-651
Main Authors: Tao, Ze-Zhang, Yamashita, T., Chou, J. T. Y.
Format: Article
Language:English
Subjects:
Animals
Hair Cells, Auditory - enzymology
Hair Cells, Auditory - ultrastructure
Hair Cells, Auditory, Inner - enzymology
Hair Cells, Auditory, Inner - ultrastructure
Mice
Mice, Neurologic Mutants
Microscopy, Electron
Mitochondria - enzymology
Succinate Dehydrogenase - metabolism
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Summary:The activity of succinate dehydrogenase in the sensory hair cells in the organ of Corti of mature and old shaker-1 mice described as the animals grew older, the outer hair cells being the most effected. The decrease inactivity of this enzyme was closely linked with the degeneration of the mitochondria. When mitochondria were absent or grossly degenerated there was no enzyme activity. It is possible that this defect is linked with the deafness in these mice.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215100102452