Serum levels of interleukin 4 and soluble CD23 in children with allergic disorders

In order to clarify the clinical significance of serum interleukin 4 (IL-4) levels, we measured serum IL-4 concentrations in allergic and non-allergic children using a highly sensitive sandwich ELISA. The limit of detection of the assay was 0.15 pg/ml in serum samples. Serum IL-4 was detected in 96....

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Bibliographic Details
Published in:European journal of pediatrics 1995-09, Vol.154 (9), p.723-728
Main Authors: OHSHIMA, Y, KATAMURA, K, MIURA, M, MIKAWA, H, MAYUMI, M
Format: Article
Language:English
Subjects:
Allergic diseases
Asthma - blood
Biological and medical sciences
Child
Child, Preschool
Conjunctivitis, Allergic - blood
Dermatitis, Atopic - blood
Female
Food Hypersensitivity - blood
General aspects
Humans
Hypersensitivity - blood
Immunopathology
Infant
Infant, Newborn
Interleukin-4 - blood
Male
Medical sciences
Receptors, IgE - analysis
Rhinitis - blood
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Summary:In order to clarify the clinical significance of serum interleukin 4 (IL-4) levels, we measured serum IL-4 concentrations in allergic and non-allergic children using a highly sensitive sandwich ELISA. The limit of detection of the assay was 0.15 pg/ml in serum samples. Serum IL-4 was detected in 96.3% (53/55) of non-allergic controls, in 92.9% (183/197) of allergic children, in 70% (7/10) of cord blood samples and in 86.7% (26/30) of neonates. The IL-4 levels in sera from non-allergic controls were relatively constant during the ages examined and all samples were under 1.5 pg/ml. In allergic children, the serum levels of IL-4 were significantly elevated, particularly at age 13-24 months. The serum levels of IL-4 did not differ in children with different clinical manifestations of allergy, such as bronchial asthma, and atopic dermatitis. The serum level of soluble CD23 (sCD23) showed an age-dependent change in allergic and non-allergic children and was significantly higher in allergic than in non-allergic infants aged 7 to 12 months, but not in other age groups. There was no significant correlation among serum levels of IL-4, sCD23 and IgE. It is suggested that the measurement of serum IL-4 and sCD23 is helpful in the examination of allergic patients in infancy and early childhood, but neither the serum level of IL-4 nor sCD23 directly reflects in vivo IgE production.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF02276715